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Publication: MOLECULAR DYNAMICS STUDY OF THE INTERACTION OF HHC-10 WITH THE MIXED POPG/POPE MEMBRANE

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Title MOLECULAR DYNAMICS STUDY OF THE INTERACTION OF HHC-10 WITH THE MIXED POPG/POPE MEMBRANE
Authors/Editors* M. NategholEslam, B. Holland, B. Tomberli, C.G. Gray
Where published* Biophysical Journal
How published* Proceedings
Year* 2010
Volume 98
Number 3
Pages 387a
Publisher Biophysical Society
Keywords
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Abstract
The selectivity (Ref.1) of various bacterialmembranes as opposed to mammalian membranes exhibited by many cationic antimicrobial peptides is poorly understood. Molecular dynamics simulations are a useful tool for exploring the underlying molecular mechanisms for this selectivity. The interaction of the cationic peptide HHC-10, a novel antimicrobial peptide recently designed through a neural network investigations of large families of antimicrobial peptides, is studied when in the vicinity of a pure POPC (mammalian model)membrane and mixed POPG/POPE (bacterial model) membrane.
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