Publication: Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy
All || By Area || By Year| Title | Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy | Authors/Editors* | JT Elliott, M Diop, KM Tichauer, T-Y Lee, KS St. Lawrence |
|---|---|
| Where published* | Journal of Biomedical Optics |
| How published* | Journal |
| Year* | 2010 |
| Volume | 15 |
| Number | 3 |
| Pages | |
| Publisher | SPIE |
| Keywords | biomedical optics, infrared spectroscopy, imaging systems, multiplexing |
| Link | |
| Abstract |
Nearly half a million children and young adults are affected by traumatic brain injury each year in the United States. Although adequate cerebral blood flow (CBF) is essential to recovery, complications that disrupt blood flow to the brain and exacerbate neurological injury often go undetected because no adequate bedside measure of CBF exists. In this study we validate a depth-resolved, near-infrared spectroscopy (NIRS) technique that provides quantitative CBF measurement despite significant signal contamination from skull and scalp tissue. The respiration rates of eight anesthetized pigs (weight: 16.2 ± 0.5 kg, age: 1-2 months old) were modulated to achieve a range of CBF levels. Concomitant CBF measurements were performed with NIRS and CT perfusion. A significant correlation between CBF measurements from the two techniques was demonstrated (r squared = 0.714, slope = 0.92, p < 0.001), and the bias between the two techniques was â2.83 mL/min/100 g (CI 0.95: â19.63 mL/min/100 g - 13.9 mL/min/100 g). This study demonstrates that accurate measurements of CBF can be achieved with depth-resolved NIRS despite significant signal contamination from scalp and skull. The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neurointensive care. |
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